The glutamate transporter GLT-1 plays a key role in terminating glutamate excitotoxicity in the synaptic cleft, and thus its dysfunction contributes to neurodegenerative diseases, such as PD, AD, and amyotrophic lateral sclerosis (ALS) [38, 40, 53, 54], and neurological diseases, such as epilepsy and stroke [17, 18, 55]. The gene discussed is SLC1A2; the disease is Alzheimer disease.