Tetraspanin-2 (Tspan2), Proteolipid protein 1 (Plp1), Nkx6-2, Fatty acid 2-hydroxylase (Fa2h), N-myc downstream regulated gene 1 (Ndrg1), and Claudin11 (Cldn11) participate in glial development and maintenance of the myelin sheath, and their dysfunction is related to spastic ataxia and hypomyelination [65–69]. Here, PLP1 is linked to spastic ataxia.