PLP1 and Huntington disease: With this insight, examination of significant DEGs in these regions highlights a number of themes; first, myelin related and OL identity genes (e.g.,MAG, MBP, MOBP, MOG, OPALIN, PLP1, CNP, and OLIG1 and OLIG2) were downregulated in OLs of all areas in HD, (Supplementary Data 8).