TPK1 and Huntington disease: Figure 7f, g shows a decrease of TPK1 (monomer and dimer) in HD patient tissue with HD grades 3 & 4 (At adjusted p-value <0.1 for 3, and <0.05 for 4), and in juvenile HD (adjusted p < 0.05), consistent with RNA expression data, whereas TPK1 dimer is increased in the R6/2 striatum (Fig. 7d, e).