With this insight, examination of significant DEGs in these regions highlights a number of themes; first, myelin related and OL identity genes (e.g.,MAG, MBP, MOBP, MOG, OPALIN, PLP1, CNP, and OLIG1 and OLIG2) were downregulated in OLs of all areas in HD, (Supplementary Data 8). The gene discussed is OLIG1; the disease is Huntington disease.