Activated CD4 T-cells with T-helper (Th) 1 and Th17/Th17.1 bias [1–3] drive granuloma formation, while abnormalities in regulatory T-cells [4] and invariant natural killer T-cells (iNKTs) [5, 6] may also contribute to this axis of pathogenesis by weakening the control of proliferation and activity of effector T-cells. This evidence concerns the gene CD4 and Granuloma.