TLR3 and pulmonary sarcoidosis: In a very small sub-study (n=3 patients), activation of TLR3 in primary lung fibroblasts from 412 F-homozygous pulmonary sarcoidosis patients resulted in reduced IFNB and TLR3 expression, and reduced apoptosis and dysregulated fibroproliferative responses compared with TLR3 wild-type patients [39].