We also assessed the kinetics of NKG2D-L expression on infected (mNeonGreen+) A549-ACE2 and found that, while NKG2D-L were downregulated to some extent at 24 h post-infection compared with uninfected cells, it was not until 48 h post-infection that we observed almost total loss of these proteins at the surface level (Figure 2E). The gene discussed is ACE2; the disease is infection.