IRAK4 and infection: Other interesting genes involved in PRR signaling pathways that were enriched in zebrafish larvae infected with S. pneumoniae PLY+ compared with infection with S. pneumoniae PLY− are irak4 (FC 1.80, q = 1.75 × 10−9) and tbk1 (FC 1.41, q = 1.54 × 10−18) (Table S1).