The 8-gene signature included three genes over-expressed in bacterial infections (SMARCD3, ICAM1, EBI3; “bacterial genes”) and five over-expressed in viral infections (JUP, SUCLG2, IFI27, FCER1A, HESX1; “viral genes”) (Figures S3A and S3B). The gene discussed is ICAM1; the disease is bacterial infectious disease.