FN1 and keloid: This protein is also highly concentratedin keloid scars where they sustain inflammation and the productionof collagen.38 The interaction betweenEDA-FN and the α4β1 integrin receptorpromotes a profibrotic contractile phenotype in dermal fibroblasts,characterized by an increase in actin stress fibers, myosin lightchain phosphorylation, and FN production.39 α4β1 is also the main regulatorof EDA-FN-dependent synthesis of cytokines by fibroblasts.39,40