Fourth, proteoforms of genes in well-known CRC-related pathways (WNT/β-catenin signaling, PI3K/AKT signaling, mTOR signaling, and ERK/MAPK signaling) are different between SW480 and SW620 cells, and those proteoforms could play vital roles in modulating CRC metastasis. Here, AKT1 is linked to colorectal carcinoma.