WNK2 and colorectal carcinoma: We further performed QIAGEN Ingenuity Pathway Analysis (IPA) analysis of the genes identified in this work by the four CZE-MS/MS–based strategies and determined several significantly enriched and well-known CRC-related pathways, including WNT/β-catenin signaling (P value: 10−3), phosphoinositide-3-kinase (PI3K)/Protein kinase B (Akt) signaling (P value: 10−4), mammalian target of rapamycin (mTOR) signaling (P value: 10−14), and extracellular signal–regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling pathways (P value: 10−4) (31, 32).