HMGN1 and liver cancer: Figure 5B shows that one HMGN1 proteoform and one RBM8A proteoform have the most significant abundance changes between SW480 and SW620 cells. HMGN1 regulates gene expression and PTMs of core histones, affecting DNA repair and tumor progression (50). It has been reported that RBM8A promotes tumor cell migration and invasion in the most common type of primary liver cancer (51).