Third, PTMs (i.e., phosphorylation) of important cancer-related genes (i.e., DAP, HDGF, JPT1, RALY, NPM1, MARK2, SOX9, EIF4B, and EIF4EBP1) could play important roles in regulating CRC metastasis, evidenced by the significant abundance differences of phosphorylated proteoforms from those genes between the SW480 and SW620 cells. The gene discussed is HDGF; the disease is colorectal carcinoma.