Although our NPC1 models showed poor accuracy using leave-one-out cross validation (Table 1), these models predicted infection status of bats with 100% accuracy; whereas trait and phylogenetic models showed only 71% accuracy (Table 3) likely due to the low sensitivity of trait and phylogenetic eigenvector models for this group, meaning the ability to identify a true positive infection status in bats is low (see S6 Table). Here, NPC1 is linked to infection.