The whole-mounted retinas in the aflibercept group also showed apparent retinal hemorrhage (arrowheads in Fig 2C), increased Ter119+ area (P = 0.04, Fig 2D), retinal vascular growth impairment (P = 0.04, Fig 2C and 2E), decreased number of branching points (P<0.01, Fig 2F and 2G), increased area of col4+CD31- regressed capillaries (P<0.01, filled arrowheads in Fig 2F and 2H), and decreased number of EdU+Erg+ proliferating ECs (P<0.01, open arrowheads in Fig 2F and 2I), in contrast to the ranibizumab groups. Here, PECAM1 is linked to Retinal hemorrhage.