Regarding tubular lesions, hematuria correlated with necrotic casts in PR3-ANCA (p = 0.012, r = 0.601, Fig. 2B), and with RBC casts in MPO-ANCA GN (p = 0.008, r = 0.577, Fig. 2C), while both associations were observable in the overall ANCA GN cohort (Fig. 2A). This evidence concerns the gene PRTN3 and ganglioneuroma.