DHDH is involved in the detoxication of trans-dihydrodiol and carcinogenic metabolites of polycyclic aromatic hydrocarbons [40]; SUCNR1 is related to conditions such as hypertension, diabetes, and obesity [41], whereas ATP8B3 is involved in aminophospholipid transport in the liver [42]. Here, SUCNR1 is linked to obesity due to melanocortin 4 receptor deficiency.