Endothelin-1 is a well-known growth factor secreted by tumor cells, regulating cellular processes through signaling via mitogen-activated protein kinase (MAPK), protein kinase B (Akt), integrin-linked kinase (ILK), and proto-oncogene tyrosine-protein kinase Src pathways (Teoh et al. 2014). This evidence concerns the gene WNK2 and neoplasm.