INS and Insulin resistance: We have noted from different datasets that over the lower end of the population range of insulinemia (median ~ 45 pmol/L: (Elshorbagy et al. 2017) and the present study), tCys did not correlate with insulin resistance, but that it was associated with insulin resistance in populations with higher insulin (mean 69 and 98 pmol/L (Elshorbagy et al. 2012d, 2018).