As part of the drug therapy, the use of insulin to control T2DM has become an increasingly common health behavior due to the high incidence of cases with uncontrolled blood sugar levels, due to the abandonment or inadequate use of oral anti-diabetic drugs (ADD), or even an insufficient response to the proposed treatment, with the emergence of negative outcomes often irreversible(9). The gene discussed is INS; the disease is type 2 diabetes mellitus.