This study was set out to present new evidence that licorice zinc can be a clinical candidate drug for the treatment of chloasma, by investigating the effect of licorice zinc on melanogenesis and P38MAPK and JNK signaling pathway in the UVB irradiation-induced chloasma model of C57BL/6J mice and α-MSH-treated B16F10 cell. The gene discussed is MAPK8; the disease is freckles.