PLOD2 and preeclampsia: Interestingly, HK2, PLOD2, and TREM1 were significantly upregulated in the early-onset preeclampsia cohort (Supplementary Figure 2A), and TREM1 was also significantly upregulated in PE patients with concomitant hemolysis, elevated liver enzymes and low platelets (HELLP) complications (Supplementary Figure 2B).