Interestingly, HK2, PLOD2, and TREM1 were significantly upregulated in the early-onset preeclampsia cohort (Supplementary Figure 2A), and TREM1 was also significantly upregulated in PE patients with concomitant hemolysis, elevated liver enzymes and low platelets (HELLP) complications (Supplementary Figure 2B). Here, HK2 is linked to preeclampsia.