CD4 and infection: When C57BL/6 mice were infected with the ME49 strain of T. gondii, activated (CD44hiCD62Llo) CD4+ and CD8+ T cell number in the ILNs was greatest during acute infection (2 wpi) (Figure 2c–d, Figure 2—figure supplement 2a), consistent with the broad distribution of parasite in peripheral tissues at this time point.