While there was no difference in the number of cDC1s (CD45+Lin-CD11chiMHC IIhiCD64-CD26+XCR1+SIRPα-) or cDC2s (CD45+Lin-CD11chiMHC IIhiCD64-CD26+XCR1-SIRPα+) in naive and acutely infected mice, by 6 weeks post-infection (wpi) there was a threefold increase in the number of cDC1s and sixfold increase in the number of cDC2s in the dural meninges (Figure 1f–g). The gene discussed is SIRPA; the disease is infection.