In addition to its function in protein trafficking, the proteinmay function as cell surface receptor to mediate acute responses toproneurotrophins.50 Expression of C1ql3 (q-value 0.003) has been shown indiscrete neuronal populations to control efferent synapse numbers;as such it may have a role in synaptic loss in AD.51 The gene discussed is CD177; the disease is Alzheimer disease.