INS and obesity due to melanocortin 4 receptor deficiency: Skeletal muscle from individuals with obesity exhibits mitochondrial impairments (Ritov et al., 2005), oxidative stress (Anderson et al., 2009), ectopic lipid accumulation (Kelley & Goodpaster, 2001), and insulin resistance (DeFronzo & Tripathy, 2009) that are believed to contribute to obesity‐related comorbidities (Blüher, 2019).