The effects of PPARγ agonists including Pio on learning and memory has been reported (Almasi‐Nasrabadi et al., 2014; Gupta & Gupta, 2012; Xiang et al., 2012); however, the effects of Pio on learning and memory impairments induced by Sco and oxidative stress indicators in the brain tissues of aged rats has not been addressed. The gene discussed is PPARG; the disease is memory impairment.