In the present study, we found that the expression level of SCN1B in all groups of hypoxia-ischemia was lower than that in the control group, and the expression level of SCN1B in the severe group of hypoxia-ischemia (30 min) was lower than that in the mild group (10 min), with the lowest at 30 min of reperfusion. The gene discussed is SCN1B; the disease is ischemia.