The NGAL gene is found to be upregulated in very early kidney injury and is a highly induced protein in the kidney after ischemic or nephrotoxic AKI in animal models (Devarajan, 2015; Devarajan et al., 2003; Mishra et al., 2003; Mishra et al., 2004; Supavekin et al., 2003). Here, LCN2 is linked to acute kidney injury.