2012; Oncel and Basson 2022). Our experiments demonstrate that OH can regulate endothelin associated with inflammation, reduce endothelin secretion, increase nitric oxide synthase activity and promote the production of nitric oxide (Figure 2). Accordingly, we speculated that well within the scope of influence and dynamic balance, ulcer tissue endothelin and nitric oxide improve the activity of SOD and GSH, lower MPO enzyme activity, decrease MDA release (Table 1) and improve oxidative inflammatory response induced by stress. This evidence concerns the gene SOD1 and ulcer disease.