These included IL‐6—known for its both pro‐ and anti‐inflammatory effects but being particularly immunosuppressive in the tumor niche (Liu et al, 2017), CXCL1 that is typically overexpressed in tumors to induce myeloid‐derived suppresser cells (Hu et al, 2021), and IL‐16 and CXCL12 known for switching macrophage M2 polarization (Dürr et al, 2010; Babazadeh et al, 2021). This evidence concerns the gene IL16 and neoplasm.