PRL and panhypopituitarism: The side effects described for this type of treatment include panhypopituitarism, optic neuropathy, cerebral vascular accident, and secondary tumors [19]. This treatment is almost never used nowadays because of the effectiveness of medical and surgical treatments in the vast majority of cases, also, because of its adverse effects and the long duration, it takes for the PRL to normalize, both for RS and FIRST [20].