CRCI, chemotherapy-related cognitive impairment; LDL, low-density lipoprotein; KEGG, Kyoto Encyclopedia of Genes and Genomes; PFS, progression-free survival; DFS, disease-free survival; HER2, human epidermal growth factor 2; OS, overall survival; T3, tumor larger than 5 centimeters; T4, tumor of any size growing into the chest wall or skin, including inflammatory breast cancer. This evidence concerns the gene ERBB2 and Cognitive impairment.