CNR2 and cancer: CB2 was associated with a variety of diseases in humans, ranging from cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, autoimmune, lung disorders to pain and cancer.14 All these diseases could be regulated via CB2, which based on some typically cellular signalling including the activation of mitogen-activated protein kinases and JUN N terminal kinases, as well as a transient increase in the intracellular calcium levels, resulting in complex physiological functions.15