Additionally, in studies involving cardiovascular disease, Wang et al. clarified that NEAT1 knockdown can improve ischemia/reperfusion-induced cardiac insufficiency in rats and LPS-induced myocardial injury in mice by inhibiting the TLR2/NF-κB signaling pathway [29]; and Du et al. demonstrated that NEAT1 aggravates the myocardial ischemia-reperfusion injury in mice by activating the MAPK signaling pathway [20]. This evidence concerns the gene TLR2 and heart failure.