BECN1 and neoplasm: Furthermore, inactivation of Beclin 1 and Atg5 increases the incidence of cancer in mice, monoallelic deletion of Beclin 1 promotes tumorigenesis, and the induction of autophagy by over‐expression of Beclin 1 inhibits tumor progression (Liang et al., 1999, Qu et al., 2003, Levine 2007).