The results of this multivariate analysis confirmed our findings on univariate analyses shown in Fig. 2A. IL-16, FGF-2, CCL8, and Leptin paired concentration were displayed, showing at the same time the secreted concentration for each patient and each tissue type (juxta-tumor on X-axis and tumor on Y-axis), and the distribution of the tumor-specific over- or under-expression (distance to the diagonal) (Fig. 2D). The gene discussed is IL16; the disease is neoplasm.