ATG4B and colorectal carcinoma: As shown in Fig. 6F-H, the growth of wild-type CRC cells (Particularly HCT116 and SW620) was significantly inhibited (typically, IC50 = 18.9 μM for WT HCT116), instead of the ATG4B knockout cell lines (IC50 = 28.1 μM for ATG4B KO HCT116).