Among participants under 45 years old, four variants had a suggestive significant interaction effect with HIV infection (rs9932976, β = − 0.09, Pinteract = 3.47 × 10–7, RBFOX1; rs9938274, β = − 0.09, Pinteract = 4.00 × 10–7, RBFOX1; rs1345439, β = 0.08, Pinteract = 6.33 × 10–7, CBLN1; rs2507941, β = 0.12, Pinteract = 8.42 × 10–7, ITGA9) (Table 3). This evidence concerns the gene ITGA9 and HIV infectious disease.