In addition, a metabolomic analysis by Kappel BA, et al. showed that treatment with empagliflozin, an SGLT2i, restored HF-induced reduction in catabolism of branched chain amino acids (BCAA), an ATP source of failing hearts [53], suggesting that the myocardial availability of valine in blood was increased by SGLT2 inhibition, which may serve as a substrate for production of L-BAIBA. This evidence concerns the gene SLC5A2 and hydrops fetalis.