SGLT2, sodium-glucose cotransporter 2; NYHA, New York Heart Association; LVEF, left ventricular ejection fraction; HFrEF, heart failure with reduced ejection fraction; eGFRcre, creatinine-based estimated glomerular filtration rate; eGFRcys, cystatin C-based estimated glomerular filtration rate; NT-proBNP, N-terminal pro-brain natriuretic peptide; HbA1c, glycated hemoglobin A1c; RASi, renin-angiotensin system inhibitor; MRA, mineralocorticoid receptor antagonist; DPP4i, dipeptidyl peptidase 4 inhibitor. The gene discussed is DPP4; the disease is heart failure.