Compared with the normal group, the IDD group presented with increases in the levels of TNF-α, IL-6, IL-1β, PGE2, ROS, MDA and ECM degradation genes, and decreases in COL II, ACAN; compared with the IDD group, the levels of TNF-α, IL-6, IL-1β, and PGE2, the activities of ROS and MDA, and ECM degradation were significantly decreased in the L-Rg1, M-Rg1, and H-Rg1 groups in a concentration-dependent manner. The gene discussed is ACAN; the disease is intervertebral disk degenerative disorder.