According to the results, the NP tissues of IDD rats showed increased levels of TNF-α, IL-6, IL-1β, and PGE2, and increased activities of ROS and MDA compared with the normal group; however, ginsenoside Rg1 could significantly decrease such increases in a dose-dependent manner (Fig. 3A–F). The gene discussed is IL1B; the disease is intervertebral disk degenerative disorder.