DCLK3 and Huntington disease: Furthermore, Galvan et al. [101] recently showed that doublecortin like kinase 3 (DCLK3) provides neuroprotection against striatal degeneration in HD, and hypothesized that DLCK3 may play a role in the transcriptional regulation of striatal genes via its interaction with ADA3, a SAGA subunit necessary for HAT activity [4].