PIEZO1 and infection: After infection with P. aeruginosa, higher bacterial loads, fewer tissue-infiltrating neutrophils (not macrophages) and decreased levels of inflammatory mediators have been found in the lungs of mice with macrophage-specific deletion of Piezo1 (Piezo1ΔLysM) than in their wild-type littermates, which suggests that Piezo1-mediated mechanotransduction in alveolar macrophages may play an anti-inflammatory role in infectious-associated ALI/ARDS [45].