Over the past decades, several types of channels, including the epithelial sodium channel/degenerin (ENaC/DEG) family, Piezo channels, transient receptor potential (TRP) superfamily, two-pore domain potassium (K2P) channels, and transmembrane channel-like 1/2 (TMC1/2) channels, have been validated as bona fide MSCs [19–23], and dysfunction of these MSCs is considered to be involved in various pathological conditions and diseases (e.g., pain, cancers, pulmonary hypertension) [24–26]. This evidence concerns the gene TMC1 and pulmonary arterial hypertension.