Pulmonary endothelial hyperpermeability and pulmonary edema induced by high-volume ventilation or increased pulmonary microvessel pressure are abrogated in endothelial-specific deletion of Piezo1 (Piezo1iEC−/−) or Piezo1-knockdown mice [29, 99], and treatment with a Piezo1 inhibitor (GsmTx-4) can attenuates lung vascular leakage and edema formation [99]. This evidence concerns the gene PIEZO1 and edema.