Additionally, SARS-CoV-2 spike protein contains an 8-mer peptide that is identical to the furin cleavage site of ENaC-α, and proteolytic cleavage of the furin site of ENaC is essential for its activation [86], SARS-CoV-2 infection may inhibit ENaC activity by hijacking the proteolysis network of ENaC, subsequently affect the AFC capacity and pulmonary edema of COVID-19 patient lungs [87]. This evidence concerns the gene SCNN1A and edema.