Endothelium-specifical deletion of Piezo1 (Piezo1iEC−/−) in mice results in pulmonary endothelial hyperpermeability and pulmonary edema, which may contribute to the reduced lung static compliance in Piezo1iEC−/− mice similar to the decreased lung compliance observed in ALI/ARDS patients [50]. Here, PIEZO1 is linked to acute respiratory distress syndrome.