KCNK4 and acute respiratory distress syndrome: Similarly, exacerbated lung injury associated with decreased surfactant protein A and C (SPA and SPC) has also observed in TREK-1/TREK-2/TRAAK triple knockout (TKO) mice compared with WT mice, which suggests that TREK-2 and TRAAK may also be involved in the development of hyperoxia-induced ALI/ARDS [32].