PIEZO1 and pulmonary edema: Excessive mechanical forces (e.g., mechanical stretch) exerted on alveolar units leading to aberrant activation of MSCs (e.g., Piezo1), and aberrant enhancement of MSC-mediated mechanotransduction subsequently activates multiple downstream signaling pathway and results in disruption of alveolar epithelial/endothelial barrier function and pulmonary edema [33, 49].