In conclusion, ZIKV infection induced microglia activation in the brain of ZIKV-infected CC071 mice susceptible to ZIKV-induced disease in correlation with higher levels of induction of the IFNB and pro-inflammatory responses as compared to PBS-treated and CC001-infected mice less susceptible to ZIKV infection, even though microglial cells from CC0071 mice were seemingly not infected by ZIKV. The gene discussed is IFNB1; the disease is Zika virus infectious disease.