As for the Trem2 gene, a regulator of inflammation in microglia, that is up-regulated at later stage 2 of DAM [27, 39] but down-regulated at early stages of AD [40], was found significantly down-regulated at 6 d.p.i. in ZIKV-infected CC071 as compared to CC001 brain (Fig. 6). This evidence concerns the gene TREM2 and Alzheimer disease.