For all the genes associated with the IFNB response (Fig. 4a), the pro-inflammatory response and the complement cascade (Fig. 4b and c) that displayed significant or near significant different expression levels in brain extracts from ZIKV-infected CC071 as compared to ZIKV-infected CC001 mice, no significant differences were observed between the two strains in the absence of infection (PBS treated mice). The gene discussed is IFNB1; the disease is infection.