ZIKV infection of PCNs treated with recIFNB did not affect the capacity of recIFNB to induce ISG expression (Fig. 2d), indicating that the delayed induction of the IFNB response in ZIKV-infected PCNs is not a consequence of ZIKV affecting IFNAR signaling in this cell type. The gene discussed is IFNB1; the disease is Zika virus infectious disease.