In order to explore the eventual correlation between ZIKV-induced DAM and pTau, the presence of pTau in the brain of PBS-treated and ZIKV-infected CC071 and CC001 mice was analyzed at 6 d.p.i. by immunofluorescence and confocal microscopy using the AT8, AT100 and AD2 Tau phosphorylation-dependent antibodies that specifically recognizes respectively the PSer202-Thr205 Tau epitope (AT8), PThr212-Ser214Tau epitope (AT100) and PSer396-Ser404 epitope (AD2) which are hallmarks of AD and other tauopathies [28, 30, 42]. Here, MAPT is linked to Alzheimer disease.