AIF1 and Zika virus infectious disease: Alongside with an enhanced expression of ZIKV RNA, we observed in vivo, in the brain of CC071 immunocompetent mice 6 d.p.i., an increased level of active Iba1 expressing microglial cells occasionally engulfing neurons, which is in agreement with results previously obtained by other groups describing high levels of microglia activation following ZIKV infection of adult mice brain [14, 18, 25, 44].