We have shown that NLRP3 deficiency decreased glutamatergic transmission to the striatal neurons, and as the striatum primarily receives glutamatergic transmission from the cortex, we then asked whether LTP induction of corticostriatal circuits (mPFC-striatum) could prevent the effects of NLRP3 deficiency on anxiety behavior. The gene discussed is NLRP3; the disease is Anxiety.