To assess the involvement of these signaling molecules in chemokine-induced migration of the various tumor cells, we tested CXCL12- and CXCL11-dependent chemotactic responses in the presence of the Erk inhibitor, PD98059, the PI-3 K inhibitor, Ly294002, and the p38 inhibitor, SB203580 (Fig. 3). The gene discussed is CXCL12; the disease is neoplasm.