To illustrate this uniqueness, NB is a super enhancers (SEs)-driven tumor characterized by high expression of SEs-targeted genes such as MYCN, PHOX2B, GATA3, HAND2, TBX2, ISL1, ASCL1, and LMO1 in transcriptional core regulatory circuitries (CRCs) [13, 17, 19]. The gene discussed is MYCN; the disease is neoplasm.