Complementing natural disease expression of PSMA in pet dogs with PCA, implantation of an immortalized canine PCA cell line (DPC-1) into immunosuppressed research dogs validated the feasibility to monitor primary PCA tumor growth and subsequent development of distant metastases using a molecular imaging strategy with SPECT/CT and PSMA-binding antibody as a radiotracer [26]. This evidence concerns the gene FOLH1 and neoplasm.