SPP1 and infection: Abf-3 is usually expressed in the intestine, and the results of this experiment indicate that the expression of Spp-1 is more sensitive to the pathogenicity of E. coli, with different pathogenicity The expression of Spp-1 was significantly up-regulated after the infection of nematodes by E. coli with different pathogenicity, which may play an early immune response at the early stage of the organism’s response to foreign pathogens, and is a rapid response and more sensitive defense mechanism.