HMGCR and hyperlipidemia: Cytochrome P450 family 7 subfamily A member 1 (CYP7A1) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) are key antioxidant enzymes that show differential expression in hyperlipidemia (Xiao-Rong et al. 2021; Hu et al. 2021).