ADAMTSL3 expression was upregulated 2-fold in LVs of patients with aortic stenosis (AS; Fig. 1a), and in the myocardium of patients with ischemic DCM (iDCM), ADAMTSL3 mRNA and protein were upregulated 1.5-fold (Fig. 1b-c). Here, ADAMTSL3 is linked to aortic stenosis.