The REpository of Molecular BRAin Neoplasia DaTa (REMBRANDT) glioma database indicates that the KCNMB3 gene, encoding the KCa1.1 β3 subunit, is expressed in a higher copy number in high-grade gliomas leading to a poorer prognosis compared to tumors expressing KCNMB2, the gene encoding the β2 subunit10. The gene discussed is KCNMB2; the disease is central nervous system cancer.