Taken together the higher sensitivity of the β3 silencing on the AA response (Fig. 3E) and the larger expression of the β3 RNA compared to other auxiliary subunits (Fig. 3A) suggest that KCa1.1 β3 may be the main auxiliary subunit associated with KCa1.1 in the membrane of glioblastoma cells. The gene discussed is KCNMA1; the disease is glioblastoma.