Heterogeneous ribonuclear protein A18 (hnRNP A18), also known as cold inducible RNA binding protein (CIRBP) is an RNA binding protein (RBP) differentially upregulated in breast, melanoma, pancreatic, and colon solid tumors in response to low oxygen tension (Chang et al., 2016; Pamboukian, 2011; Yang and Carrier, 2001; Yang et al., 2006; Yang et al., 2010). This evidence concerns the gene CIRBP and digestive system cancer.