GJA1 and neoplasm: This implies that miR-183-5p is in synch with the validated Cx43/miR-182 axis; meaning when Cx43 is down (acting as a tumor suppressor) and miR-183-5p is up (acting as an oncomiR) at low tumor grades, they are associated with poor prognosis, while when Cx43 is up and miR-183-5p is down at high tumor grades, they are associated with poor prognosis.