To understand the potential mechanism of action of miR-183-5p in breast cancer, IPA was used and revealed that the experimentally validated and predicted mRNA target(s) downstream of miR-183-5p in breast cells and tissues were (1) PDCD4, FOXO1 and BTRC (involved in invasion and proliferation pathways) and (2) MMP9, NFKB1, PTEN, SMAD4, TCF4, WNT2B, WNT5A and ZEB-1 (involved in epithelial polarity pathways). Here, SMAD4 is linked to breast cancer.