Here, we report an increased VEGF secretion in BRAFMut cells, identify transmembrane receptor tyrosine kinase ROR2 and its ligand WNT5A as upregulated in BRAFV600E melanomas, and show that both ROR2 and WNT5A are regulated by RAF-MEK-ERK and play a critical role in the angiogenic profile of BRAFV600E melanomas. Here, MAP2K7 is linked to melanoma.