HIF-1α expression has been reported to be significantly higher in 30 melanoma cell lines compared with non-transformed melanocyte cell lines, and introduction of BRAFV600E has been found to increases HIF-1α stabilisation, although HIF-1α expression was shown to be suppressed by siRNA-mediated depletion of either WT or mutant BRAF [15]. Here, BRAF is linked to melanoma.