Hutchinson-Gilford Progeria Syndrome (HGPS) is the most characteristic progeroid laminopathy caused by a de novo point mutation at position 1824 of LMNA. In HGPS fibroblast cells, a subset (12%) of compartments eventually undergoes switching (Chandra et al. 2015), and chromatin compartmentalization strength and Lamin A/C-heterochromatin interactions are globally reduced compared to that in the normal cell line. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.