CTCF is downregulated in patients with heart failure, and deletion of Ctcf in mice leads to heart failure and 3D chromatin reorganization (Lee et al. 2019a; Rosa-Garrido et al. 2017), including 99% loss of chromatin loops, TAD disruption, and A/B compartment switching in nearly 4% of the genome. The gene discussed is CTCF; the disease is heart failure.